Lung Ground-glass Opacities Clinical Trial
Official title:
Watchful Waiting for Patients With Multifocal Ground-glass Opacities: a Single-arm, Multi-center, Phase III Trial (ECTOP-1021)
This study is a single-arm, multi-center, phase III trial conducted under the Eastern Cooperative Thoracic Oncoloy Project (ECTOP) with the identification number ECTOP-1021. The primary objective of the study is to assess the overall survival of patients with multifocal ground-glass opacities by employing a watchful waiting approach rather than opting for surgical resection.
The trial aims to confirm the hypotheses that delaying surgery until GGO nodules exhibit progression or meet certain criteria offers a prognosis equivalent to those undergoing immediate surgical resection, potentially allowing many of these patients to avoid surgery altogether. Surgical criteria are met if any of the lesions exhibit progression (with a maximal diameter increase of more than 1.5mm or the apperance of a solid component) or as determined by each institution. ;