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Assessment of Salbutamol Effect on Arterial Oxygenation in COPD Patients During One-lung Ventilation

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
Assessment of Salbutamol Effect on Arterial Oxygenation in COPD Patients During One-lung Ventilation

Clinical Trial Summary

One-lung ventilation (OLV) is essential part of anesthesia during thoracic procedures. However, OLV induces a drastic increase of intrapulmonary shunt due to maintained pulmonary perfusion through the nonventilated lung, which may result in severe hypoxemia. Although the protective mechanisms of hypoxic pulmonary vasoconstriction favorably modulate pulmonary perfusion to the ventilated lung, the effect is attenuated in patients with history of chronic obstructive pulmonary disease (COPD), which alters compliance of the pulmonary artery. Salbutamol is a selective short-acting beta2-agonist and when inhaled during OLV, it acts selectively on the pulmonary vasculature reducing pulmonary vascular resistance of well-ventilated lung. We hypothesized that inhaled salbutamol would alleviate ventilation-perfusion mismatch during OLV of COPD patients, and aimed to assess the effects of salbutamol on oxygenation in these patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05914285
Study type Interventional
Source Yonsei University
Contact Young Jun Oh
Phone 82-2-2224-1636
Email yjoh@yuhs.ac
Status Recruiting
Phase N/A
Start date April 25, 2023
Completion date April 21, 2025
View Details
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