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Clinical Trial Summary

Hemophagocytic lymphohistiocytosis (HLH) associated with hematologic malignancies (HM-HLH) is a syndrome with an abysmal prognosis (10-30% 5 years overall survival). We have recently established an improved diagnostic and prognostic index for HM-HLH, termed the Optimized HLH Inflammatory (OHI) index. The OHI index is comprised of the combined elevation of soluble CD25 (sCD25) > 3,900 U/mL and ferritin >1,000 ng/mL . However, the true incidence and outcomes of HLH/OHI+ in an unselected cohort are unknown and so is the mechanism of HM-HLH.


Clinical Trial Description

The investigators will enroll patients with new/transformed hematologic malignancies. We will follow the patients until the end of the study, report their survival at one year and examine their prognosis. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05882175
Study type Observational
Source Meir Medical Center
Contact Adi Zoref Lorenz, MD
Phone 513 6525610
Email adi.zoref.lorenz@cchmc.org
Status Recruiting
Phase
Start date March 3, 2021
Completion date March 3, 2026

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