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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT05813002
Other study ID # REC-22-06-04-S
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date April 2023
Est. completion date May 2023

Study information

Verified date April 2023
Source University of Sharjah
Contact Ibrahim M [imoustafa], Professor
Phone +971502180024
Email iabuamr@sharjah.ac.ae
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

the main objective of this study is to investigate if different neurodynamic test sequencing of the median nerve has a different impact on median nerve root function. We hypothesized that the order of median nerve neurodynamic movements would influence peak-to-peak amplitude and latency.


Description:

Neurodynamic concept is used clinically to normalize nerve mobility. It has been manifested in previous studies that neurodynamics have increased mobility by floss like movement of the nerve. Whereas in other studies it has been concluded that neurodynamic techniques has an effect in decreasing fibrous and adhesions between neural tissues and the surrounding tissues therefore giving an outcome of improved infrafasicular gliding. The upper limb neurodynamic test has an effect to alter the mechanical loads on the nerve by changing its dimensions. For neurodynamic to be more effective, it requires a certain sequence. The different order of movements will induce different duration of tension in which it will influence the nerve root function, which is needed to be investigated to check for the effectiveness. A previous study has found that the difference of sequence on median nerve, had caused a change on the distribution of the sensory response on the asymptomatic participants. The sensory responses were more prevalent during the neurodynamic of the median nerve when it was applied from a distal to proximal sequence . One of the main purposes of the order of sequences is to add more strain to the nerve segment to increase the sensitivity of the test. Clinically it has been assumed that the different order of movements could possibly influence the level of strain on a certain nerve segment. When the standard sequence was compared with the distal-to-proximal sequence for the median nerve, there was no physiological difference obtained at the end of the test. In comparison, there was a larger strain in the distal-to-proximal sequence in comparison to the proximal-to-distal sequence observed. However, the longitudinal excursion collected data indicated that the start and end positions for all the three sequences were alike. In terms of neurophysiological outcomes, in this study we will use the dermatomal somatosensory evoked potential as a primary outcome due to its reliability in comparison with other physiological outcomes. There is a literature gap in regard to the effect of the order of sequence on the median nerve on the nerve root function and this is what the study will focus on. We hypothesized that the order of movements of the median nerve neurodynamic will influence the peak-to-peak amplitude and the latency.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 75
Est. completion date May 2023
Est. primary completion date May 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria: - not currently experiencing any neck or dominant upper extremity symptoms. - do not have a history significant for a chronic painful condition. - do not using pain relievers. Exclusion Criteria: - inflammatory joint disease or other systemic pathologies. - prior history of overt injury and surgery relating to the musculoskeletal system. - disorder related to the spine and extremities. - musculoskeletal pain in the last three months

Study Design


Related Conditions & MeSH terms

  • Physical and Rehabilitation Medicine

Intervention

Other:
standard neural mobilization
is a movement-based intervention aimed at restoring the homeostasis in and around the nervous system.
Distal to proximal neural mobilization
is a distal to proximal movement-based intervention aimed at restoring the homeostasis in and around the nervous system.
proximal to distal neural mobilization
is a proximal to distal movement-based intervention aimed at restoring the homeostasis in and around the nervous system.

Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
University of Sharjah

Outcome

Type Measure Description Time frame Safety issue
Primary Change in dermatomal somatosensory evoked potentials. In all dermatomes, 2 complete recording runs will be undertaken during each session with averages of 250 to 1200 cortical responses from scalp surface recording electrodes (C3'-C4' in a 10-20 electrode configuration) of the contralateral scalp to the stimulated dermatomes being stimulated. The impedance of ground and scalp electrodes will be maintained at < 5 k Cutaneous areas of C5,C6,C7 sensory roots will be stimulated in lower limb with the electrical impulses of 0.2 ms duration, frequency of 3.3 Hz and intensity 3 times higher than the sensory threshold will be determined individually for each subject. baseline (pre-treatment) and immediately after the treatment
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