Necrotizing Enterocolitis of Newborn Clinical Trial
Official title:
The Role and Mechanism of Intestinal Dysbacteriosis Impairing the Intestinal Mucosal Barrier in the Pathogenesis of Necrotizing Enterocolitis in Premature Infants
Study Description The goal of this observational study is to detect intestinal flora and the metabolic products in premature infants diagnosed as necrotizing enterocolitis. The main questions it aims to answer are: - 1. Whether there is intestinal flora in the stool of premature infants. - 2. Are there dysregulated intestinal flora and their metabolic products in premature infants diagnosed as necrotizing enterocolitis. - 3. The detailed role and underlying mechanism of the intestinal dysbacteriosis and the metabolic products in premature infants diagnosed as necrotizing enterocolitis. Participants, premature infants diagnosed as necrotizing enterocolitis (NEC group), will be asked to collect stool (usually 2 times) for intestinal flora analysis. If there is a comparison group: Researchers will compare premature infants without necrotizing enterocolitis (control group) to see if their intestinal flora and the metabolic products also changed as their NEC counterparts.
When the patients is hospitalized in neonatology, we screen the premature infants according to the selection criteria and exclusion criteria. After sighed the informed consent, they are classified into two groups: premature infants diagnosed as necrotizing enterocolitis (NEC group) and premature infants without necrotizing enterocolitis (control group). Their stool and blood (usually 2 times ) are collected for intestinal flora and FABP (including L-FABP and I-FABP) analysis, respectively. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03926390 -
Gut Priming With Oral Bovine Colostrum for Preterm Neonates; Randomized Control Trial
|
N/A | |
| Recruiting |
NCT03111329 -
Does Routine Assessment of Gastric Residuals in Preterm Neonates Influence Time Taken to Reach Full Enteral Feeding?
|
N/A | |
| Recruiting |
NCT03549507 -
CEUS Evaluation of Bowel Perfusion in Necrotizing Enterocolitis
|
Phase 3 | |
| Completed |
NCT04977817 -
Probiotics/TPN in the NICU
|
||
| Completed |
NCT03136172 -
Monitoring of Systemic or Organ Perfusion for Preterm Infants
|
||
| Completed |
NCT04719546 -
Risk Factors of Necrotizing Enterocolitis in Premature Newborns
|
||
| Recruiting |
NCT03366584 -
The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates
|
Phase 4 | |
| Recruiting |
NCT04083638 -
The Relationship Between Erythrocyte Transfusion and Nutrition and Necrotizing Enterocolitis in Preterm Infants
|
||
| Not yet recruiting |
NCT05710575 -
Role of Probiotic Use in Outcomes of Premature Birth
|
N/A | |
| Recruiting |
NCT05121753 -
Infant Formula Feeding and Necrotizing Enterocolitis in Newborns
|
||
| Recruiting |
NCT03997266 -
NICU Antibiotics and Outcomes Trial
|
Phase 4 |