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Clinical Trial Summary

Pupillary examination, and in particular pupillary reactivity to light, is fundamental to the monitoring and follow-up in intensive care units of patients with acute brain injury. A pupillometric index combining different parameters of pupillary light reflex has been described as predictive of intracranial hypertension and the neurological outcome of the patient.


Clinical Trial Description

Pupillary examination, and in particular pupillary reactivity to light, is fundamental for the monitoring and follow-up in intensive care units of patients with acute brain injury. Intracranial pressure monitoring and pupillometry measurement are thus part of the routine practice of intensive care unit management of brain injured patients. Furthermore, elevated intracranial pressure in brain injured patients admitted to the ICU is associated with a poor prognosis, and very high intracranial pressure is a life-threatening situation. A pupillometry index combining different parameters of pupillary light reflex has been described as having predictive value of intracranial hypertension and neurological outcome of the patient: the "NPi". Another manufacturer IdMed, Marseille, France proposes an index: the QPI (Quantitative Pupillometry Index), based on a statistical classification of the amplitude of the light reflex. The aim of this study is to show that : - QPI is equivalent to NPI - An abnormal value of the pupillometry indexes (NPI/QPI) is predictive of high intracranial pressure. - An abnormal value of pupillometry indexes (NPI/QPI) is predictive of a poor neurological outcome at 6 months. ;


Study Design


NCT number NCT05567978
Study type Observational [Patient Registry]
Source University Hospital, Grenoble
Contact PIERRE BOUZAT
Phone 0476766729
Email pbouzat@chu-grenoble.fr
Status Recruiting
Phase
Start date October 31, 2022
Completion date December 30, 2024