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Arginine-stimulated Indication of Early Outcome After Islet Transplantation — ALADDIN  

Diabetes Mellitus Clinical Trial

Official title:
Arginine-stimulated Indication of Early Outcome After Islet Transplantation

Clinical Trial Summary

Through islet transplantation, functional β-cell mass can be restored. Allogeneic islet transplantation is a treatment modality for a select group of patients with complicated type 1 diabetes mellitus. For patients undergoing (partial) pancreas resection, autologous islet transplantation may help prevent complicated diabetes. Up until now, no studies have been performed on early islet graft function in the first week after transplantation. Early graft function may be a predictor for estimating long-term islet graft success. Arginine can excite β-cells to release insulin. It can thus provide an estimate of β-cell secretory capacity and can be used as an alternative to (oral) glucose tolerance tests. In this study, we aim to find a predictor model for islet graft function by assessing peak C-peptide after arginine stimulus in the early post-transplantation phase.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05540197
Study type Observational
Source Leiden University Medical Center
Contact
Status Enrolling by invitation
Phase
Start date February 23, 2023
Completion date October 2025
View Details
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