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5-HT3 Receptor Antagonist and Respiratory Drive in Patients With ARDS — DRIVE  

Acute Respiratory Distress Syndrome Clinical Trial

Official title:
Effect of a 5-HT3 Receptor Antagonist on Respiratory Drive in Spontaneously Breathing Mechanically Ventilated Patients With Acute Respiratory Distress Syndrome (ARDS): a Pilot Proof-of-concept Crossover Non-randomized Controlled Trial

Clinical Trial Summary

This is a pilot study aimed at acquiring primary physiological data, describing and estimating the effects of a 5-HT3 receptor antagonist (ondansetron) on respiratory drive in patients with acute respiratory distress syndrome (ARDS). The results of this study will determine the interest and feasibility of assessing the clinical applications of ondansetron in reducing patient self-inflicted lung injury (P-SILI) in ARDS, in subsequent studies.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05514483
Study type Interventional
Source Hopital du Sacre-Coeur de Montreal
Contact Virginie Williams
Phone 514-338-2222
Email virginie.williams.cnmtl@ssss.gouv.qc.ca
Status Recruiting
Phase Phase 4
Start date November 10, 2022
Completion date May 6, 2024
View Details
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