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Study of Quality of Life Post Salpingo-oophorectomy in BRCA1/2 & PALB2 Mutation Carriers (BRCA-HRT) — BRCA-HRT  

Hereditary Breast and Ovarian Cancer Clinical Trial

Official title:
Study of Quality of Life Post Preventive Salpingo-oophorectomy in Healthy BRCA1/2 and PALB2 Mutation Carriers

Clinical Trial Summary

1. Premenopausal BRCA1 / 2 or PALB2 gene mutation carriers who receive hormone replacement therapy (HRT) after preventive salpingo-oophorectomy (PBSO) have a better quality of sexual, psychological, cardiovascular and bone health than carriers who decline HRT. 2. Premenopausal mutation carriers treated with PBSO who choose HRT have a comparable overall survival and specific survival for breast / gynecological cancer to women who undergo surgery and refuse to receive HRT. 3. Premenopausal mutation carriers treated with PBSO have better overall and specific breast / gynecological cancer survival than non-SOBP carriers.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Hereditary Breast and Ovarian Cancer
  • Hereditary Breast and Ovarian Cancer Syndrome
Clinical Trial Details
NCT number NCT05409222
Study type Observational
Source Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Contact Teresa Ramon y Cajal, MD PhD
Phone + 34 93 556 56 38
Email tramon@santpau.cat
Status Recruiting
Phase
Start date March 12, 2020
Completion date October 2023
View Details
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