Serum Copeptin in Cirrhotic Patients With Spontaneous Bacterial Peritonitis

Spontaneous Bacterial Peritonitis Clinical Trial

Official title:

Serum Copeptin in Cirrhotic Patients With Spontaneous Bacterial Peritonitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05401721
• Other study ID #: Soh-Med-21-04-24
• Status: Completed
• Start date: May 1, 2021
• Est. completion date: December 1, 2021

Study information

• Verified date: May 2022
• Source: Sohag University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Current reports have demonstrated that copeptin predicts disease progression and prognosis in cirrhotic patients, independent of liver-specific scoring systems. To the best of our knowledge, few studies have addressed the association between copeptin and sepsis in cirrhotic patients, however, they were performed on different types of infections. Therefore, we will conduct this study with a focus on it is possible role in patients with SBP.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 89
• Est. completion date: December 1, 2021
• Est. primary completion date: December 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• The diagnosis of liver cirrhosis will be based on clinical data and findings on abdominal ultrasound. The diagnosis of SBP will be based on the presence of at least 250 cells/ml PMNLs in the ascitic fluid, with or without positive ascitic fluid culture in the absence of hemorrhagic ascites and secondary peritonitis

Exclusion Criteria:

• Patients with heart failure, coronary insufficiency, advanced chronic respiratory disease, polyuria-polydipsia syndrome and hypotension or shock.
• Patients with chronic kidney disease treated with hemodialysis before admission.
• Patients with previous liver or kidney transplantation.
• Patients with intraabdominal malignancy.
• Patients with severe infection other than SBP.
• Patients who had received antibiotics before hospital admission.

Related Conditions & MeSH terms

• Peritonitis
• Spontaneous Bacterial Peritonitis

Intervention

Diagnostic Test:
• Serum copeptin
Blood test

Locations

Country	Name	City	State
Egypt	Sohag Faculty of Medicine	Sohag

Sponsors (1)

Lead Sponsor	Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	compare serum levels of copeptin in cirrhotic patients with and without SBP	compare serum levels of copeptin in cirrhotic patients with and without SBP	6 months
Secondary	assess serum copeptin levels in different stages of cirrhosis and its relationship with kidney and circulatory function	assess serum copeptin levels in different stages of cirrhosis and its relationship with kidney and circulatory function	6 months