Clinical Trials Logo
  1. Home
  2. Other
  3. NCT05154617

Assessment of Oxygen Delivery as an Early Predictor of Postoperative Pulmonary Complications During One-lung Pulmonary Ventilation in Thoracic Surgery. A Pilot Study — DO2 and POPCs  

Postoperative Pulmonary Complications Clinical Trial

Official title:
Assessment of Oxygen Delivery as an Early Predictor of Postoperative Pulmonary Complications During One-lung Pulmonary Ventilation in Thoracic Surgery. A Pilot Study

Clinical Trial Summary

This is a simple descriptive pilot study where 60 patients undergoing One-lung ventilation (OLV) for > 120 minutes during esophagectomy will be enrolled to see if the Flo Trac® system can identify hypoxemia earlier than the standard of care monitoring.

Clinical Trial Description

One-lung ventilation (OLV) is necessary to facilitate surgical exposure in thoracic surgery. OLV can lead to hypoxemia due to the collapse of the non-dependent lung with potentially increased atelectasis in the dependent lung. Hypoxemia, the low oxygen level in the blood, during OLV can be detected by a decrease in arterial hemoglobin oxygen saturation (SaO2) measured by pulse oximetry (SpO2%). Although the incidence of hypoxemia during OLV is currently considered less than 4%, SaO2 is not well correlated to the oxygen supply to the tissues, determined by oxygen delivery (DO2), thus normal values of SaO2 can be associated with abnormal values of DO2 and on the contrary, hypoxemic values of SaO2 can be associated with normal values of DO2. Hypoxemia in patients with cardiovascular, cerebrovascular and/or pulmonary disease leads to an increased risk of complications related to low oxygen supply. Postoperative pulmonary complications (POPCs) can lead to increased perioperative morbidity and mortality, increased incidence of admission to an intensive care unit, prolonged hospital stay and increased medical cost. To the best of our knowledge, there are no studies in thoracic surgery, including esophagectomies, where intraoperative Oxygen Delivery (DO2) or DO2 index (DO2i) is used as a strategy for early detection of POPCs. There are also no studies that have determined the critical level of DO2 and DO2i or Percentage of Oxygen Extraction (O2ER) and Percentage of Oxygen Extraction index (O2ERi) in thoracic surgery associated with POPCs. The aim of this study is to determine if the use of DO2 and DO2i as a continuous non-invasive monitor of oxygen supply to the tissues during OLV, may help us determine the critical DO2 and DO2i to predict POPCs. ;

Study Design

Related Conditions & MeSH terms

  • Postoperative Pulmonary Complications
Clinical Trial Details
NCT number NCT05154617
Study type Interventional
Source University Health Network, Toronto
Contact Jacobo Moreno Garijo, MD
Phone (416) 340-4800
Email Jacobo.Moreno@uhn.ca
Status Not yet recruiting
Phase N/A
Start date January 2022
Completion date October 2023
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06021249 - Comparing Innovative and Traditional Ventilation Strategies on Atelectasis and Prognosis in Elderly Patients N/A
Not yet recruiting NCT06023017 - The Effect of Preoperative Prone Position Training on PPCs in Patients Undergoing Laparoscopic Sleeve Gastrectomy N/A
Active, not recruiting NCT06304779 - The Effect of Continuous Intravenous Infusion of Lidocaine on PPCs and Prognosis in Emergency Surgical Patients With IAI N/A
Completed NCT03688724 - Perioperative Diaphragm Point of Care Ultrasound
Not yet recruiting NCT05519657 - Incidence and Risk Factors of PPCs in Elderly Patients Undergoing Robot Assisted Laparoscopic Pelvic Surgery
Recruiting NCT06150079 - Individualized PEEP Titration on Postoperative Pulmonary Complications N/A
Completed NCT04605250 - Respiratory Variability for Respiratory Monitoring During the Postoperative Recovery Period N/A
Not yet recruiting NCT02732574 - Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery N/A
Not yet recruiting NCT05830474 - Effect of Continuous Intra-airway Monitoring Under Visible Double-lumen Bronchial Catheter on Postoperative Complications of Lung Surgery N/A
Completed NCT05401253 - The Association of Different Levels of Physical Activity on Postoperative Pulmonary Complications in Patients Undergoing Thoracoscopic Lung Resection Surgery
Not yet recruiting NCT06304493 - REMINDers for Incentive Spirometry in PACU (REMIND-IS in PACU) N/A
Completed NCT02918877 - Anesthetics to Prevent Lung Injury in Cardiac Surgery Phase 1/Phase 2
Not yet recruiting NCT06396767 - Diaphragmatic Inspiratory Amplitude as a Prognosticator for Postoperative Pulmonary Complications After Cardiac Surgery
Recruiting NCT04408495 - Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients N/A
Recruiting NCT05515809 - Evaluation of the Effect of Para-sternal Block on Postoperative Respiratory Function After Cardiac Sternotomy Surgery Phase 3
Recruiting NCT05922449 - Using Thoracic Paravertebral Block for Perioperative Lung Preservation During VATS Pulmonary Surgery N/A
Recruiting NCT04108130 - An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study N/A
Not yet recruiting NCT05671939 - Different Algorithm Models to Predict Postoperative Pulmonary Complications in Elderly Patients
Not yet recruiting NCT05671952 - Multi-center Study on Reducing Postoperative Pulmonary Complications in Elderly Patients N/A
Not yet recruiting NCT05671926 - Different Algorithm Models to Predict Postoperative Pneumonia in Elderly Patients