Other Clinical Trial - Oral Combined Hydrochlorothiazide/Lisinopril Versus

Status Active, not recruiting

Clinical Trial Summary

The purpose of this study is to see if a combined pill of Angiotensin-converting enzyme (ACE) inhibitors (a medication that helps relax your veins and arteries to lower your blood pressure) with diuretics (sometimes called water pills, help rid your body of salt and water) will control blood pressure better than a different blood pressure medication of calcium channel blocker (lower your blood pressure by preventing calcium from entering the cells of your heart and arteries). Both medications are part of our usual care for high blood pressure after delivery.

Clinical Trial Description

In individuals with preeclampsia, persistent hypertension and edema result in part from the mobilization of up to 8 liters of fluid and sodium from the extravascular to intravascular space. The increased urinary sodium excretion on days 3-5 postpartum likely results from higher atrial natriuretic peptide concentrations in plasma and activation of the renin-angiotensin-aldosterone system. Adding diuretics for postpartum hypertension has been associated with better blood pressure control in some of the studies. - CVD is the leading cause for mortality worldwide. - Primary prevention is more effective than treating CVD. - Pregnancy is often the 1st adult engagement with the healthcare system. - Preeclampsia is a risk factor for long term CVD, even after controlling for mutual risk factors. - CVD is the leading cause for pregnancy related mortality. - There is no good data regarding the optimal medications to control blood pressure after delivery. - ACE inhibitors play an important role in controlling blood pressure outside of pregnancy and there is extensive evidence to support their cardioprotective effects. - The optimal use of diuretics in the postpartum in patients with preeclampsia, require further study and clarification to augment current management schemes. Hypothesis: that in postpartum women with hypertensive disorders, oral combined Hydrochlorothiazide/Lisinopril will reduce postpartum hypertension at 7 days after delivery compared to usual care with calcium channel blockers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05049616
Study type	Interventional
Source	The University of Texas Health Science Center, Houston
Contact
Status	Active, not recruiting
Phase	Phase 4
Start date	October 18, 2021
Completion date	October 1, 2023

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See also
Status	Clinical Trial	Phase
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Terminated	`NCT03595982` - Is Procardia XL 60 mg Q Daily Equivalent to 30 mg XL Given Twice Daily?	Phase 4
Completed	`NCT04486170` - Assessment of Postpartum Education to Improve Compliance	N/A
Completed	`NCT03506724` - Response to Anti-hypertensives in Pregnant and Postpartum Patients	Phase 4
Completed	`NCT03613714` - Innovation in Postpartum Care for Women With Hypertensive Disorders of Pregnancy	N/A
Recruiting	`NCT04604535` - The BEET-BP Trial - Investigating the Effect of Dietary Nitrates on Hypertension in Pregnancy	N/A
Completed	`NCT00412230` - Insulin Resistance and Hypertensive Disorders in Pregnancy	N/A
Completed	`NCT04119232` - Randomized Clinical Trial to Increase Physical Activity After a a Hypertensive Pregnancy	N/A
Completed	`NCT04633551` - Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes	N/A
Completed	`NCT05859282` - Development and Validation of a Short Tool to Assess the Awareness of Pregnancy-induced Hypertension
Active, not recruiting	`NCT05543265` - Bridging the Gap From Postpartum to Primary Care	N/A
Completed	`NCT00571766` - Effects of Oral L-Arginine on Chronic Hypertension in Pregnancy	Phase 3
Recruiting	`NCT05473767` - Expanding the Family Check-Up in Early Childhood to Promote Cardiovascular Health of Mothers and Young Children	N/A
Recruiting	`NCT05683093` - Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
Completed	`NCT06403722` - Perinatal Outcomes in Patients With Elevated sFlt-1/PlGF Ratio
Recruiting	`NCT05852054` - Supporting Transitions to Primary Care Among Under-resourced, Postpartum Women (STEP-UP)	Phase 3
Recruiting	`NCT05137808` - Understanding Blood Pressure Changes After Birth
Completed	`NCT03961360` - Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida	Phase 2/Phase 3
Active, not recruiting	`NCT03648645` - Hypertensive Pregnant Women Monitored by Teletransmitted Self-measurements of Blood Pressure	N/A
Recruiting	`NCT06054841` - Reshaping Postpartum Follow-up	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension — ACE

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms