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Clinical Trial Summary

Current treatments for relapsed/refractory hematopoietic malignancies such as B-cell lymphomas (BCLs) and peripheral T-cell lymphomas (PTCLs) are far from satisfactory. CD5 is widely expressed in multiple subtypes of BCLs and PTCLs but rarely found in normal tissues except certain types of lymphocytes. Chimeric antigen receptor (CAR) T cells against CD5 offer another potential therapeutic option for patients with relapsed/refractory CD5 positive hematopoietic malignancies. In the current study, the safety and efficacy of a novel CAR T cell therapy, termed CT125A cells, are evaluated in patients with relapsed/refractory CD5+ hematopoietic malignancies. The endogenous CD5 in CT125A cells is knocked out via CRISPR/Cas9 genome editing technology to prevent fratricide during CAR T cells manufacturing.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04767308
Study type Interventional
Source Huazhong University of Science and Technology
Contact Jianfeng Zhou, PhD, MD
Phone 86-27-83662680
Email jfzhou@tjh.tjmu.edu.cn
Status Not yet recruiting
Phase Early Phase 1
Start date March 2021
Completion date December 2023

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