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Clinical Trial Summary

Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce plasma glucose and haemoglobin A1c(HbA1c) in patients with type 2 diabetes mellitus by increasing urinary glucose excretion in a non-insulin-dependent fashion. However, in some situations lead to a diminished number of functional glomeruli with a consequent hyperfiltration in the remaining ones. This fact may be where the use of SGLT2 inhibitor could attenuate the renal damage. The purpose of our study is to evaluate the impact of using dapagliflozin on the renal functional deterioration of renal transplanted patients diabetics or not. This is a prospective, randomized, single-blinded, double-center, controlled trial. Patients will be randomized to add either Dapagliflozin 10 mg or Placebo to their treatment. Study drug will be administered by once-daily orallly. The first dose MUST be started within 1 and 7 days after randomization. The subsequent doses will be administered 24 ± 4 hours after the previous dose.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04743453
Study type Interventional
Source University of Sao Paulo General Hospital
Contact Elias David-Neto, MD,PhD
Phone 55-11-2661-8089
Email pesquisaclinicautr.ichc@hc.fm.usp.br
Status Recruiting
Phase Phase 4
Start date August 17, 2021
Completion date August 1, 2023

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