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Early Use of Hyperimmune Plasma in COVID-19 — COV-II-PLA  

Covid19 Clinical Trial

Official title:
COVID-19 Wave II Study for Assessing the Early Use of Hyperimmune Plasma for the Treatment of COVID-19 Patients Needing Non-invasive or Invasive Mechanical Ventilation

Clinical Trial Summary

The study assesses the efficacy of early administration of hyperimmune plasma in covid-19 patients who are on CPAP or intubated. Efficacy is measured as a 2 point decrease in the WHO scale

Clinical Trial Description

Patients who satisfy eligibility criteria and in particular have started positive pressure respiratory support not more than no more than 48 hours are administered 200 to 300 ml in 2 or 3 times administered over a time window of 5 days. . Plasma titration will depend on the availability in the local Plasma Bank; any titre ≥ 1:80 will be acceptable. primary endpoint will be assessed at 28 days; vital status will be further investigated at 3 and 6 months. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04721236
Study type Interventional
Source IRCCS Policlinico S. Matteo
Contact
Status Active, not recruiting
Phase N/A
Start date November 19, 2020
Completion date May 19, 2022
View Details
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