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Clinical Trial Summary

This is a Phase 1/2, open-label, multi-center, single arm basket study evaluating the administration of lerapolturev ± anti programmed cell death protein 1 (PD 1)/programmed death-ligand 1 (PD L1) monoclonal antibody (mAb) (which will be referred to throughout this protocol as "anti-PD-1/L1 therapy") therapy in adult patients with solid tumor cancers. Non-muscle invasive Bladder Cancer has been selected as the tumor specific cancer of interest for enrollment.


Clinical Trial Description

Patients with recurrent non-muscle invasive bladder cancer (NMIBC) intended for transurethral resection of bladder tumor (TURBT) or cystectomy will receive lerapolturev by intravesical instillation. Approximately 12-15 patients will be enrolled. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04690699
Study type Interventional
Source Istari Oncology, Inc.
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date August 1, 2021
Completion date May 2025

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