Inflammatory Myofibroblatic Tumor Clinical Trial
Official title:
Study on the Molecular Profile and Molecular Signature of Inflammatory Myofibroblastic Tumor
Gene mutation is a research hotspot in the occurrence of multiple malignant tumors. The somatic gene mutations of many different types of tumors not only help to study the tumorigenesis mechanism and molecular diagnosis, but also can be used as an ideal therapeutic target. Large-scale gene profiling studies performed by humans in various types of epithelial tumors have confirmed some new gene mutations. However, there are few reports on the detection of genes related to inflammatory myofibroblastic tumor, and humans have not yet understood its molecular content. Therefore, it is necessary to further use molecular detection methods to explore the molecular markers of IMT to facilitate its follow-up precise treatment plan.
Inflammatory myofibroblastic tumor（IMT）is a rare clinical mesenchymal tissue-derived tumor,
which can occur in almost all organs and soft tissues, and is characterized by low-grade or
borderline tumors.
The diagnosis of inflammatory myofibroblastic tumor is mainly based on histopathology and
immunohistochemistry. The treatment is resistant to conventional chemotherapy and
radiotherapy. The only curative treatment is complete surgical resection. When IMT shows
typical cellular structural features in pathology, the diagnosis is relatively simple.
However, in the presence of atypical features, the accurate diagnosis of IMT is still a
challenge. Therefore, it is necessary to explore a better diagnostic method. Secondly, there
is no individualized treatment method for aggressive IMT patients who relapse and metastasize
after surgery. At present, gene mutation is a research hotspot in the occurrence of various
malignant tumors. The somatic gene mutations of many different types of tumors not only help
to study the tumorigenesis mechanism and molecular diagnosis, but also can be used as an
ideal therapeutic target. Large-scale gene profiling studies performed by humans in various
types of epithelial tumors have confirmed some new gene mutations. However, there are few
reports on the detection of inflammatory myofibroblastic tumor, and humans have not yet
understood its molecular content. Therefore, it is necessary to further use molecular
detection methods to explore the molecular markers of IMT to facilitate its follow-up precise
treatment plan.
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