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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT04522336
Other study ID # 2019-1253
Secondary ID NCI-2020-0525120
Status Active, not recruiting
Phase Phase 1
First received
Last updated
Start date September 16, 2020
Est. completion date July 18, 2024

Study information

Verified date February 2024
Source M.D. Anderson Cancer Center
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This phase I trial investigates how well pembrolizumab and chemoradiotherapy works in treating patients with gastroesophageal cancer that cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as fluorouracil, oxaliplatin and docetaxel work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy photons to kill tumor cells and shrink tumors. Giving pembrolizumab together with chemoradiotherapy may help to control gastroesophageal cancer.


Description:

PRIMARY OBJECTIVE: I. To evaluate the clinical activity (as assessed by complete clinical response rate) of pembrolizumab plus chemoradiation. SECONDARY OBJECTIVES: I. To evaluate the safety and tolerability of pembrolizumab plus chemoradiation. II. To determine the overall survival efficacy of pembrolizumab plus chemoradiation. III. Evaluate progression free survival (PFS) by local investigator review and by blinded central radiologists' review. EXPLORATORY OBJECTIVES: I. To explore the association between PD-L1 expression by immunohistochemistry, somatic gene expression profiling, and clinical efficacy of pembrolizumab. II. To explore the relationship between genomic variation and response to study treatment. III. To identify molecular (genomic, metabolic, and/or proteomic) biomarkers that may correlate with clinical response/resistance, safety, pharmacodynamic activity, and/or the mechanism of action of pembrolizumab in combination with chemoradiation. IV. To determine the effect of pembrolizumab plus chemoradiation treatment on tumor T cell infiltration. OUTLINE: INDUCTION CHEMOTHERAPY: Patients receive pembrolizumab intravenously (IV) over 30 minutes on day 1. Treatment with pembrolizumab repeats every 3 weeks for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients also receive oxaliplatin IV over 2 hours on day 1 followed by fluorouracil IV over 48 hours once every 2 weeks (Q2W) for 8 weeks (4 cycles) in the absence of disease progression or unacceptable toxicity. CONSOLIDATION CHEMORADIATION: After a 3 week treatment free period, patients receive pembrolizumab IV over 30 minutes on day 1. Treatment with pembrolizumab repeats every 3 weeks for up to 2 cycles in the absence of disease progression or unacceptable toxicity. Patients also receive fluorouracil IV continuous over 5 days (Monday through Friday) for 5 weeks and docetaxel IV over 1 hour once a week (QW) for 5 weeks in the absence of disease progression or unacceptable toxicity. Starting no later than 3 days after the beginning of the Consolidation Chemoradiation period, patients also undergo 28 fractions of radiation therapy in the absence of disease progression or unacceptable toxicity. After a 6-9 week treatment free period, patients continue pembrolizumab IV over 30 minutes on day 1. Treatment with pembrolizumab repeats every 3 weeks for up to 30 cycles in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 30 days, then every 9-12 weeks thereafter.


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 16
Est. completion date July 18, 2024
Est. primary completion date July 18, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Participants with histologically confirmed diagnosis of unresectable gastroesophageal adenocarcinoma will be enrolled in this study for systemic treatment first - Have histologically documented locally advanced unresectable cancer or localized cancer in a patient who declines surgery - Participant is able to provide endoscopic research biopsies and research blood - Participant has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, as assessed within 7 days prior to treatment initiation - A male participant must agree to use a contraception during the treatment period and for at least 120 days, corresponding to time needed to eliminate any study treatment(s) after the last dose of study treatment and refrain from donating sperm during this period - A female participant is eligible to participate if she is not pregnant, not breastfeeding, and at least one of the following conditions applies: - Not a woman of childbearing potential (WOCBP) OR - A WOCBP who agrees to follow the contraceptive guidance during the treatment period and for at least 120 days/weeks after the last dose of study treatment - Patients with stable brain metastasis and/or carcinomatous leptomeningeal disease as defined in exclusion criteria - The participant (or legally acceptable representative if applicable) provides written informed consent for the trial. The participant may also provide consent for future biomedical research. However, the participant may participate in the main trial without participating in future biomedical research - Absolute neutrophil count >= 1500/uL (within 10 days prior to the start of study treatment) - Platelets >= 100 000/uL (within 10 days prior to the start of study treatment) - Hemoglobin >= 9.0 g/dL or >= 5.6 mmol/L (within 10 days prior to the start of study treatment) - Criteria may be met with blood transfusion as these tumors are losing blood - Creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated* creatinine clearance (CrCl) >= 60 mL/min for participant with creatinine levels > 1.5 x institutional ULN (within 10 days prior to the start of study treatment) (GFR can also be used in place of creatinine or CrCl) - Creatinine clearance (CrCl) should be calculated per institutional standard - Total bilirubin =<1.5 x ULN OR direct bilirubin =< ULN for participants with total bilirubin levels > 1.5 x ULN (within 10 days prior to the start of study treatment) - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x ULN (within 10 days prior to the start of study treatment) - International normalized ratio (INR) OR prothrombin time (PT), activated partial thromboplastin time (aPTT) =< 1.5 x ULN unless participant is receiving anticoagulant therapy as long as PT or aPTT is within therapeutic range of intended use of anticoagulants (within 10 days prior to the start of study treatment) Exclusion Criteria: - Has cancer that is confined to the stomach and not involving gastroesophageal junction - Has significant cardiovascular impairment within 6 months of the first dose of study drug (New York Heart Association [NYHA] class III or IV) - Has had major surgery, open biopsy, or significant traumatic injury within 28 days prior to randomization, or anticipation of the need for major surgery during the course of study treatment - Note: If participant has had major surgery, they must have recovered adequately from the toxicity and/or complications from the treatment prior to starting study intervention - Has pre-existing peripheral neuropathy > grade 1 - Participant has a history of (non-infectious) pneumonitis that required treatment with steroids or currently has pneumonitis - Participant has a known additional malignancy that is progressing or has required active treatment in the last 2 years - Note: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, ductal carcinoma in situ, or cervical carcinoma in situ that has undergone potentially curative therapy are not excluded - Participant has known active central nervous system (CNS) metastases and/or carcinomatous meningitis - Note: Participants with previously treated brain metastases may participate provided they are radiologically stable (i.e., without evidence of progression for at least 4 weeks by repeat imaging [repeat imaging should be performed during study screening]), clinically stable, and without requirement for steroid treatment for at least 14 days prior to the first dose of study treatment - Participant has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of study treatment - Participant has an active autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs) - Note: Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment - Participant has an active infection requiring systemic therapy - Participant has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the participant's involvement for the full duration of the trial, or is not in the best interest of the participant to be involved, in the opinion of the treating investigator - Note: Participants who received colony-stimulating factors (e.g., granulocyte colony stimulating factor [G-CSF], granulocyte macrophage colony-stimulating factor [GM-CSF] or recombinant erythropoietin) within 2 weeks prior to the first dose of study treatment are not eligible - Participant has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial - Participant has a known history of human immunodeficiency virus (HIV) infection. No HIV testing is required unless mandated by local health authority - Participant has a known history of hepatitis B (defined as hepatitis B surface antigen [HBsAg] reactive) or known active hepatitis C virus (defined as HCV ribonucleic acid [RNA] [qualitative] is detected) infection. No testing for hepatitis B or hepatitis C is required - Participant has received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T cell receptor (e.g., CTLA-4, OX 40, CD137) - Participant has received prior systemic anti-cancer therapy including investigational agents - Has received prior radiotherapy for the current disease - Participant has received a live vaccine within 30 days prior to the first dose of study treatment. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines and are not allowed - Participant has severe hypersensitivity (>= grade 3) to pembrolizumab or any of its excipients - Participant is currently participating in or has participated in a study of an investigational agent (anti-cancer agent only) or has used an investigational device within 4 weeks prior to the first dose of study treatment - Note: Participants who have entered the follow-up phase of an investigational trial may participate as long as it has been 4 weeks after the last dose of the previous investigational agent - Participant is pregnant or breastfeeding or expecting to conceive children within the projected duration of the study, starting with the screening visit through 120 days after the last dose of study treatment - Participant has symptomatic ascites or pleural effusion. A participant who is clinically stable following treatment for these conditions (including therapeutic thoraco- or paracentesis) is eligible - Has had an allogeneic tissue/solid organ transplant

Study Design


Related Conditions & MeSH terms

  • Adenocarcinoma
  • Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Esophageal Neoplasms
  • Localized Gastroesophageal Junction Adenocarcinoma
  • Locally Advanced Gastroesophageal Junction Adenocarcinoma
  • Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Unresectable Gastroesophageal Junction Adenocarcinoma

Intervention

Drug:
Docetaxel
Given IV
Fluorouracil
Given IV
Oxaliplatin
Given IV
Biological:
Pembrolizumab
Given IV
Radiation:
Radiation Therapy
Receive radiation therapy

Locations

Country Name City State
United States M D Anderson Cancer Center Houston Texas

Sponsors (2)

Lead Sponsor Collaborator
M.D. Anderson Cancer Center National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Other Tumor PD-L1 proportion Up to 2 years
Other Tumor gene expression Up to 2 years
Other Tumor genetics Up to 2 years
Other Biomarker analysis Up to 2 years
Other Tumor T cell infiltrate Up to 2 years
Primary Clinical complete response (cCR) cCR, defined as at the time of post-chemoradiation staging, there is no evidence of cancer on endoscopic examination/histology/cytology and there is no evidence of cancer by imaging modality. Tumor assessment will be conducted every 9 weeks until the 54th week of the study and every 12 weeks after that. The best response will be recorded. Up to 2 years
Secondary Number of participants experiencing adverse events (AEs) Safety and tolerability will be assessed by clinical review of all relevant parameters including AEs, laboratory tests, and vital signs. Counts and percentages of subjects with AEs will be provided. Up to 90 days post treatment
Secondary Number of participants discontinuing study drug due to AEs Safety and tolerability will be assessed by clinical review of all relevant parameters including AEs, laboratory tests, and vital signs. Counts and percentages of subjects with AEs will be provided. Up to 90 days post treatment
Secondary Overall survival (OS) OS will be estimated using Kaplan-Meier method. From start of treatment to death due to any cause, assessed up to 2 years
Secondary Median progression free survival (PFS) PFS will be estimated using Kaplan-Meier method. From date of first dose with study drug to the earliest date of progression or death by any cause (in the absence of progression), assessed up to 2 years
Secondary PFS at 6 months PFS will be estimated using Kaplan-Meier method. From date of first dose with study drug to the earliest date of progression or death by any cause (in the absence of progression), assessed at 6 months
Secondary PFS at 12 months PFS will be estimated using Kaplan-Meier method. From date of first dose with study drug to the earliest date of progression or death by any cause (in the absence of progression), assessed at 12 months
Secondary PFS at 24 months PFS will be estimated using Kaplan-Meier method. From date of first dose with study drug to the earliest date of progression or death by any cause (in the absence of progression), assessed at 24 months
See also
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Not yet recruiting NCT05296005 - Neoadjuvant Therapy for the Treatment of Gastroesophageal Junction and Gastric Cancers Phase 1
Suspended NCT03604991 - Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery Phase 2/Phase 3
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Recruiting NCT05836584 - Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer Phase 2
Active, not recruiting NCT04097028 - Use of Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy for the Treatment of Resectable Esophageal or Gastroesophageal Junction (GEJ) Adenocarcinoma Phase 2
Recruiting NCT04704661 - Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Patients With Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial Phase 1

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