Abnormalities of Urinary Analysis Clinical Trial
Official title:
Acute Kidney Injury and Renal Outcomes for COVID-19 Patients in Intensive Care Units
NCT number | NCT04459975 |
Other study ID # | CoV-AKI_2020 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | April 1, 2020 |
Est. completion date | November 2020 |
The actual COVID-19 epidemy is an unprecedented healthcare problem. Although acute
respiratory distress syndrome is the main organ failure, acute kidney injury (AKI) has
appeared to be more frequent and more severe than expected. Some data suggested a potential
direct renal tropism of the virus, or undirect injury by "cytokine storm".
The aims of this study are:
1. To describe incidence, severity and mortality associated with AKI during covid-19
infection in ICU
2. To identify specific risk factors for AKI
3. To explore pathophysiologic mechanism of AKI during COVID-19 infection
Status | Recruiting |
Enrollment | 200 |
Est. completion date | November 2020 |
Est. primary completion date | October 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Confirmed COVID-19 infection (by qRT-PCR and/or TDM typical lesion) - Needing intensive care Exclusion Criteria: - End Stage Renal Disease patients (with pre-existent dialysis) - Intensive care support for less than 72h (transfer in conventional unit or death) |
Country | Name | City | State |
---|---|---|---|
France | Intensive care units attached to the Hospices Civils de Lyon (HCL) | Lyon |
Lead Sponsor | Collaborator |
---|---|
Hospices Civils de Lyon |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Primary endpoint is the incidence, the severity and the mortality associated with AKI during COVID-19 severe infection | AKI will be defined according with KDIGO guidelines: increase in creatinine of more than 1,5 fold compared to baseline Severe CVOID-19 infection is defined as 1/ confirm COVID-19 infection (by TDM and/or qRT-PCR) 2/ Requirement of ICU support during more than 72h | 7 months |