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A Study of SGN-B6A in Advanced Solid Tumors

Esophageal Squamous Cell Carcinoma Clinical Trial

Official title:
A Phase 1 Study of SGN-B6A in Advanced Solid Tumors

Clinical Trial Summary

This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors. It will study sigvotatug vedotin to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether sigvotatug vedotin works to treat solid tumors. The study will have four parts. - Part A of the study will find out how much sigvotatug vedotin should be given to participants. - Part B will use the dose found in Part A to find out how safe sigvotatug vedotin is and if it works to treat solid tumors. - Part C of the study will find out how safe sigvotatug vedotin is in combination with these other drugs. - Part D will include people who have not received treatment. This part of the study will find out how safe sigvotatug vedotin is in combination with these other drugs and if these combinations work to treat solid tumors. - In Parts C and D, participants will receive sigvotatug vedotin with either: - Pembrolizumab or, - Pembrolizumab and carboplatin, or - Pembrolizumab and cisplatin.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04389632
Study type Interventional
Source Seagen Inc.
Contact Seagen Trial Information Support
Phone 866-333-7436
Email clinicaltrials@seagen.com
Status Recruiting
Phase Phase 1
Start date June 8, 2020
Completion date October 31, 2028
View Details
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