Aortic Stenosis (Treated With TAVI) Clinical Trial
Official title:
Effect of Preoperative Iron Isomaltoside 1000 Administration on Hemoglobin Concentration in Patients Undergoing Transcatheter Aortic Valve Implantation: a Randomized Clinical Trial
Transcatheter aortic valve implantation (TAVI) is a standard procedure for severe aortic
stenosis patients with moderate or higher risk of surgery. Several studies have reported the
adverse effects of blood disorders, such as anemia and iron deficiency, on the prognosis of
patients undergoing TAVI, and many other studies have been conducted to find ways to prevent
them.
Iron isomaltoside, the latest intravenous iron supplement, can effectively replenish iron
store with a single high-dose injection. Research has shown that a preoperative single
high-dose iron isomaltoside (1000mg) safely increased hemoglobin levels after surgery in
patients undergoing cardiac surgery. However, there have been no studies on the effect of
ultra-short-term use of intravenous iron supplements prior to TAVI procedure.
Therefore, we investigate the effect of a single high-dose of iron isomaltoside (20mg/kg,
maximum dose: 1g) on the hemoglobin concentration after the TAVI.
n/a