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Monitoring of Cerebral Autoregulation in Pediatric ECMO (ECMOX 1) — ECMOX1  

Extracorporeal Membrane Oxygenation Complication Clinical Trial

Official title:
Monitoring of Cerebral Autoregulation in Pediatric ECMO (ECMOX 1)

Clinical Trial Summary

Children supported by Extra-Corporeal Membrane Oxygenation (ECMO) present a high risk of neurological complications and cerebral autoregulation (CA) impairment may be a risk factor. Our first objective is to investigate the feasibility of CA continuous monitoring during ECMO treatment. The second objective is to analyze the relationship between CA impairment and neurological outcome.

Clinical Trial Description

Patients : All children treated by ECMO in the PICU of the Universitary hospital of Nantes, France and of IRCCS Giannina Gaslini Institute, Genoa, Italy

Measurements: A correlation coefficient between the variations of regional cerebral oxygen saturation (rScO2) as a surrogate of cerebral blood flow and the variations of arterial blood pressure (ABP) is calculated as an index of autoregulation (cerebral oxygenation index (COx), ICM+ software®). CA is monitored either on left (COxl) or both sides. A COx > 0.3 is considered as critical. Neurological outcome is assessed by the onset of an acute neurologic event (ANE) during the ECMO run. ;

Study Design

Related Conditions & MeSH terms

  • Extracorporeal Membrane Oxygenation Complication
Clinical Trial Details
NCT number NCT04282525
Study type Observational
Source Nantes University Hospital
Contact
Status Completed
Phase
Start date June 1, 2018
Completion date June 1, 2019
View Details
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