Acute Primary Angle-closure Glaucoma Clinical Trial
Official title:
Laser Peripheral Iridotomy Induced Changes in Corneal Densitometry in Acute Primary Angle Closure Glaucoma Cases
Purpose: Our purpose was to investigate the laser peripheral iridotomy (LPI) induced changes
in corneal densitometry in acute primary angle closure glaucoma (PACG) cases during the
post-laser 1 month period.
Material and methods: This prospective study included 21 eyes of 21 cases with first acute
attack of PACG. All the eyes underwent LPI with neodymium: yttrium-aluminum-garnet (Nd: YAG)
laser after the intraocular pressure (IOP) decreased to normal levels with maximal systemic
and topical anti-glaucoma treatment and complete regression of clinically significant corneal
edema. Central corneal thickness (CCT) and corneal density values were measured by
densitometry software of Pentacam HR-Scheimpflug corneal topography over a 12-mm diameter of
the cornea just before LPI and at the first week and the first month after LPI. Kolmogorov
smirnov and paired-t tests were used for statistical analysis.
This prospective study included 21 eyes of 21 cases with first acute attack of PACG who had
applied to emergency department of Ulucanlar Eye Research Hospital between March 2018 and
January 2019. All the eyes underwent LPI with neodymium: yttrium-aluminum-garnet (Nd: YAG)
laser after the IOP decreased to normal levels with maximal systemic and topical
anti-glaucoma treatment and complete regression of clinically significant corneal edema.
During the acute attack ocular examination was performed at the emergency department
including best-corrected visual acuity (BCVA) with Snellen charts, slit-lamb examination,
fundus examination by +90 D lens, IOP measurements with Goldmann applanation tonometry,
gonioscopy of the fellow eye with Goldmann three-mirror lens. Gonioscopy and fundus
examinations were performed for the eyes with acute PACG after the regression of corneal
edema.
All the cases had intravenous infusion of mannitol 20% (250-300 cc) at the emergency
department. Oral acetazolamide 250 mg (3 times daily), oral potassium supplement, topical
fixed-combination of beta-blocker and carbonic anhydrase inhibitors (twice daily) and
brimonidine (twice daily). LPI procedures were performed within the first day of the attack
(after 12-24 hours) by the same experienced physician (OA) with neodymium:
yttrium-aluminum-garnet (Nd: YAG) laser under topical anesthesia with proparacain %0.5.
Superior-nasal position (1 or 11 o'clock) was focused and 1 or more shots were performed (1-3
pulses per shot with 3-8 mJ energy).
Central corneal thickness (CCT) and CD values were measured by densitometry software of
Pentacam HR-Scheimpflug corneal topography just before LPI and at the first week and the
first month after LPI. All the measurements were performed by the same experienced clinician
between 9 am and 2 pm under standard dim-light conditions without pupil dilatation.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01266343 -
Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma
|
N/A |