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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04209309
Other study ID # 13-101-0117
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 1, 2014
Est. completion date July 1, 2016

Study information

Verified date December 2019
Source University of Regensburg
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Hyper- and hyposexuality occur frequently in a variety of psychiatric disorders and are difficult to treat. While there is meta-analytic evidence for the significant effect of non-invasive brain stimulation on drug and food craving, no study has investigated the potential of this technique to modulate sexual behavior. The efficacy of a single session of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the left or right dorsolateral prefrontal cortex (DLPFC) to reduce sexual arousal was tested against a sham stimulation.

To test this hypothesis, we employed a randomized, double-blind, sham-controlled crossover study design. Nineteen healthy male participants received high-frequency rTMS over the left DLPFC, high-frequency rTMS over the right DLPFC and sham rTMS (each 10 Hz; 110% resting motor threshold; 60 trains with 50 pulses) in randomized and counterbalanced order with a one-week interval between stimulation sessions to avoid carryover effects. Participants were exposed to neutral and sexual cues before and after each intervention and rated their sexual arousal after each block of cue presentation.


Recruitment information / eligibility

Status Completed
Enrollment 19
Est. completion date July 1, 2016
Est. primary completion date July 1, 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria:

- motor threshold below 55%

- informed consent

- male

- 18-50 years

- heterosexual

- right handedness

Exclusion Criteria:

- contraindication for TMS

- somatic or mental illnesses

- intake of psychoactive drugs

- left handedness

- homo- or bisexual

- paraphilia

Study Design


Related Conditions & MeSH terms

  • Transcranial Magnetic Stimulation

Intervention

Device:
repetitive transcranial magnetic stimulation


Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
University of Regensburg

Outcome

Type Measure Description Time frame Safety issue
Primary Change of sexual arousal short 10-item version of the Affect and Arousal Scale, which captures perceived genital, autonomic and psychological sexual arousal as well as state sexual desire immediately before and after the single session of rTMS
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