Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
The Effect of Respiratory Training With Normocapnic Hyperpnea on Exercise Tolerance in COPD
Exercise intolerance is one of the key disabling factors in patients with chronic obstructive
pulmonary disease (COPD). Although multifactorial, exercise intolerance involves
physiological interactions between respiratory and locomotor muscles that may contribute to
further reducing exercise tolerance in COPD. The respiratory muscle work during exercise is
closely related to breathing and could induce respiratory muscle fatigue in patients with
COPD.
Respiratory muscle training is an intervention strategy that is sometimes proposed for some
patients with COPD, especially whose with inspiratory muscle weakness. It was reported that
inspiratory muscle training improves inspiratory muscle endurance and strength, dyspnea and
exercise tolerance. There are two types of inspiratory muscle training, inspiratory muscle
training against a resistive loading and normocapnic hyperpnoea. The advantage of normocapnic
hyperpnoea compared to resistive training is the possibility to simulate the exercise
ventilation level while maintaining stable the partial pressure of arterial carbon dioxide
and end-tidal pressure of carbon dioxide and to solicit the inspiratory and expiratory
muscles together, which could increase respiratory muscle tolerance and avoid their fatigue
during whole-body exercise.
Therefore, the aim of this project is to study the effect of normocapnic hyperpnoea training
on exercise tolerance in patients with COPD.
We hypothesize that greater improvement in cycling exercise tolerance will be observed
following 6-weeks normocapnic hyperpnoea training compared to a sham intervention in patients
with COPD.
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