Study of Hemostatic Profile in Traumatic Patients Clinical Trial
Official title:
Global Hemostasis Monitoring in Patients With Severe Trauma Using Sonoclot Signature Compared to Conventional Coagulation and Platelet Parameters
1. Analyzing the effects of severe trauma using sonoclot analyzer (which depicts the entire
hemostatic pathway) ,subsequently describing the convenient therapy .
2. Assessing the correlations between sonoclot variables and conventional coagulation and
platelet function tests
Coagulopathy is a physiological response to massive bleeding that frequently occurs after
severe trauma and is an independent predictive factor for mortality[2]. . There are two of
the major causes of coagulopathy in trauma patients
1. coagulopathy secondary to hemorrhagic shock due to massive bleeding and
2. coagulopathy secondary to severe head injury[3] which results in release of tissue
factor from damaged brain tissue.
Therefore, it is very important to grasp the coagulation status of patients with severe
trauma quickly and accurately with objective indicator in order to establish the therapeutic
strategy .
The importance of viscoelastic devices in understanding the disease condition of patients
with traumatic coagulopathy has been widely recognized in Europe. Viscoelastic hemostatic
assays devices have practical advantages as point-of-care devices for monitoring major
hemorrhage including speed of results and a set of parameters that assesses a global
coagulation profile .
Also In the USA, Massive Transfusion in Trauma Guidelines proposed by the American College of
Surgeons in 2013 presented the test results obtained by the viscoelastic devices, as the
standard for transfusion or injection of blood plasma, cryoprecipitate, platelet concentrate,
or anti-fibrinolytic agents in the treatment strategy for traumatic coagulopathy and
hemorrhagic shock .
However, some studies have reported limitations of these viscoelastic devices
;