Advanced Hepatocellular Carcinoma Clinical Trial
Official title:
Anlotinib Hydrochloride Capsules Combined With Sintilimab Injection in the Treatment of Advanced Hepatocellular Carcinoma (HCC) Open, Single Arm, Exploratory Clinical Trial
This is a single-arm, open-label and exploratory clinical study of Anlotinib Hydrochloride
Capsules combined with Sintilimab injection in the treatment of advanced Hepatocellular
Carcinoma (HCC).
In oder to observe and evaluate the efficacy and safety of Anlotinib Hydrochloride Capsules
combined with Sintilimab injection. Subjects with pathological confirmed Hepatocellular
Carcinoma will be enrolled.
21 days as a treatment cycle, Anlotinib 12mg/day(D1-D14 ) and Sintilimab injection 200mg Q3W
(D1). Sintilimab injection will be administered until disease progressioncor un-tolerable
toxicity. Anlotinib will be administered until disease progression. If anlotinib is not
tolerated, the dose can be reduced to 10mg or 8mg ,until un-tolerable toxicity again.
This is a single-arm, open-label and exploratory clinical study of Anlotinib Hydrochloride Capsules combined with Sintilimab injection in the treatment of advanced Hepatocellular Carcinoma (HCC).In oder to observe and evaluate the efficacy and safety of Anlotinib Hydrochloride Capsules combined with Sintilimab injection.subjects with pathological confirmed Hepatocellular Carcinoma will be enrolled.21 days as a treatment cycle, Anlotinib 12mg/day(D1-D14 ) and Sintilimab injection 200mg Q3W (D1). Sintilimab injection will be administered until disease progressioncor un-tolerable toxicity. Anlotinib will be administered until disease progression. If anlotinib is not tolerated, the dose can be reduced to 10mg or 8mg ,until un-tolerable toxicity again. ;
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