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Clinical Trial Summary

The aim of this proposal is to test if anti-BAFF antibody can restore a normal threshold of tolerance in patients in two auto-immune diseases along the RITUX-PLUS study in immune thrombocytopenia, and along the Believe study in SLE. This work would help to conclude whether or not the 'double hit' therapy may help to reset the immune system toward a more tolerogenic profile. The aim is to compare the polyreactivity and autoreactivity, of immature (central tolerance) and naïve B cells (peripheral tolerance) in the peripheral blood along the RITUX-PLUS STUDY and the BLISS BELIEVE study after treatment (B-cell reconstitution time).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03975361
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact Mahevas Matthieu
Phone 01 49 81 20 76
Email matthieu.mahevas@aphp.fr
Status Recruiting
Phase N/A
Start date April 29, 2021
Completion date April 29, 2022

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