Acute Respiratory Distress Syndrome Clinical Trial
Official title:
Determination of the Best Positive End-expiratory Pressure (PEEP) Based on Oxygenation or Driving Pressure in Patients With Acute Respiratory Distress Syndrome After Cardiac Thoracic Surgery
Determination of the best positive end-expiratory pressure (PEEP) based on oxygenation or
driving pressure in patients with acute respiratory distress syndrome (ARDS) after
cardiothoracic surgery
The use of a positive end-expiratory pressure in acute respiratory distress syndrome is
obvious in ARDS management. On the one hand it serves to fight against the reduction of
functional residual capacity (FRC) and enable the limitation of hypoxia; and on the other
hand it allows the limitation of "opening/closing" lesions in pulmonary alveoli which lead to
increase "bio trauma".
However elevated PEEP has harmful effect such as hemodynamic effect on the right ventricle
and distension on healthy part of the lung.Other adverse effects are: decreasing cardiac
output, increased risk of barotrauma, and the interference with assessment of hemodynamic
pressures.
Ideally the adjustment of PEEP level must be done by taking into account each patient
characteristic. PEEP titration based on blood gas analysis is one of the most used techniques
by physicians.
Current guidelines for lung-protective ventilation in patients with acute respiratory
distress syndrome (ARDS) suggest the use of low tidal volumes (Vt), set according to ideal
body weight (IBW) of the patient, and higher levels of positive end-expiratory pressure
(PEEP) to limit ventilator-induced lung injury (VILI). However, recent studies have shown
that ARDS patients who are ventilated according to these guidelines may still be exposed to
forces that can induce or aggravate lung injury.
Driving pressure (DP) is the difference between the airway pressure at the end of inspiration
(plateau pressure, Ppl) and PEEP.
Driving pressure may be a valuable tool to set PEEP. Independent of the strategy used to
titrate PEEP, changes in PEEP levels should consider the impact on driving pressure, besides
other variables such as gas exchange and hemodynamics. A decrease in driving pressure after
increasing PEEP will necessarily reflect recruitment and a decrease in cyclic strain. On the
contrary, an increase in driving pressure will suggest a non-recruitable lung, in which
overdistension prevails over recruitment.
The main purposes of this study are to assess the optimal PEEP based on the best driving
pressure or the best oxygenation.
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