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Immune Damage and Vaccination in COPD Patients — ALTIBPCO  

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
Immune Damage and Vaccination in COPD Patients

Clinical Trial Summary

Better understanding of the specificities of the vaccine response in patients with COPD

Clinical Trial Description

Chronic obstructive pulmonary disease (COPD) will become the third leading cause of death worldwide in 2020 (3.5 million patients, 16500 deaths in France). Its socio-economic cost is related to the handicap induced by the decline of the respiratory function, as well as to the occurrence of exacerbations, main causes of hospitalization and mortality. Since exacerbations are mostly infectious, a preventive strategy involves routine influenza vaccination. Although it is highly recommended in this population, there is no formal evidence of its effectiveness during COPD. While correlates of influenza vaccine efficacy exist, cellular and humoral responses to this vaccine have been poorly evaluated in these patients. This alteration of the vaccine response could also be integrated into an overall deficit of the response to a vaccine in these patients. As influenza virus infection is one of the most important causes of death in patients with COPD, and vaccination is the best way to prevent it, it is essential to better understand the immune response in the context of vaccination in this population. The investigator's hypothesis is that there would be a global alteration of the immunological immune response in the COPD patient involving abnormalities of lymphocyte B differentiation and the effector capacity of T lymphocytes, notably through the activation of the PD1 / PDL1 axis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03804138
Study type Observational
Source Centre Hospitalier Intercommunal Creteil
Contact
Status Completed
Phase
Start date October 9, 2018
Completion date February 3, 2023
View Details
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