Neutrophil Extracellular Traps; Antiphospholipid Antibody-induced Pregnancy Loss Clinical Trial
Official title:
Neutrophil Extracellular Traps Mediate Antiphospholipid Antibody-induced Pregnancy Loss
1. Establish a multi-platform detection system for neutrophil extracellular traps in blood
and tissues, and evaluate the detection performance;
2. Comparing the expression levels of neutrophil extracellular traps in peripheral blood
and decidua of patients with antiphospholipid antibody-induced pregnancy loss and normal
control group;
3. Comparing the expression levels of neutrophil extracellular traps in peripheral blood
and decidua of mice with antiphospholipid antibody-induced pregnancy loss and normal
control group;
4. After treatment of antiphospholipid antibody-induced mouse abortion model with
metformin,the effect of metformin on embryo loss rate and viable embryo body weight was
observed.
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