Human Papillomavirus-Related Carcinoma Clinical Trial
Official title:
MRI Guided Brachytherapy for HPV-Associated Cervical and Vaginal Malignancies
This trial studies how well magnetic resonance imaging (MRI)-guided internal radiation therapy (brachytherapy) works in treating participants with human papillomavirus (HPV) associated stage IB2-IV cervical or stage II-IVA vaginal cancer. Using MRI guidance during brachytherapy applicator placement may improve treatment planning in participants with cervical or vaginal cancer.
PRIMARY OBJECTIVES: I. Determine whether MRI guidance during internal radiation therapy applicator placement improves the high-risk clinical target volume (HR-CTV) D90 (dose to 90% of the high-risk clinical target volume) rate compared to conventional guidance, with ultrasound and freehand technique, for patients with cervical and vaginal cancer. SECONDARY OBJECTIVES: I. Identify diffusion weighted MRI image features that can be used to identify sites of viable tumor following external beam radiotherapy as assessed by tumor aspirate cytology. II. Determine if diffusion weighted MRI findings are associated with immune infiltration as assessed by multi-spectral flow cytometry. III. Identify potential correlates between clinical outcomes (survival, progression) and these data objectives (brachytherapy dosimetry/therapeutic ratio, diffusion-weighted MRI imaging features, tumor aspirate cytology findings). IV. Define the financial costs and feasibility of an MRI-guided brachytherapy approach to determine the overall healthcare quality value (outcomes/cost) of this novel approach for application at other brachytherapy centers. OUTLINE: Participants undergo MRI scan during internal radiation therapy applicator placement. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT02379520 -
HPV-16/18 E6/E7-Specific T Lymphocytes, Relapsed HPV-Associated Cancers, HESTIA
|
Phase 1 | |
| Completed |
NCT02624349 -
Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients
|
Phase 4 | |
| Recruiting |
NCT04474821 -
HPV Educational Intervention to Increase Acceptance and Completion of Free HPV Vaccination Among Underserved Adults
|
Phase 4 | |
| Withdrawn |
NCT05472220 -
Alpelisib in Combination With Carboplatin in Patients With Solid Tumors and HPV-Positive Squamous Cell Carcinoma
|
Phase 1 | |
| Active, not recruiting |
NCT02568566 -
Recombinant Human Papillomavirus Nonavalent Vaccine in Preventing Human Papilloma Virus in Younger Healthy Participants
|
Phase 2 | |
| Not yet recruiting |
NCT05985681 -
Testing RG1-VLP Vaccine to Prevent HPV-related Cancers
|
Phase 1 | |
| Completed |
NCT04189003 -
Molecular Signatures of HPV+ ORL Cancers (OROPAP)
|
||
| Recruiting |
NCT04927650 -
Prevention and Early Detection of Cervical Cancer Through Self-Administered Screening
|
||
| Completed |
NCT01769560 -
MeFirst: A Tailored Intervention to HPV Vaccine Decision Making
|
N/A | |
| Recruiting |
NCT05831540 -
Clinical Decision Support Tools to Increase Human Papillomavirus (HPV) Vaccination in Adolescents in Pharmacies
|
N/A | |
| Recruiting |
NCT05232851 -
A Vaccine (PDS0101) Alone or in Combination With Pembrolizumab for the Treatment of Locally Advanced Human Papillomavirus-Associated Oropharynx Cancer
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT04580446 -
HYHOPE: De-intensified Hypofractionated Radiation Therapy for HPV-associated Oropharynx Cancer
|
Phase 1 | |
| Not yet recruiting |
NCT04142398 -
Incidence of HPV Infection and HPV-Associated Disease in Screening Indian Men Who Have Sex With HIV-Positive Men
|
||
| Completed |
NCT04880837 -
Human Papillomavirus Education Programs
|
N/A |