Haemostasis Imbalance in Chronic Liver Disease Clinical Trial
Official title:
Haemostatic Imbalance in Patients With Chronic Liver Disease- Its Relation to Severity and Outcome
To assess the level of protein C, S ,antithrombin in patients with liver cirrhosis To correlate the level of these parameters with the degree of liver cirrhosis To correlate the level of procoagulants with the level of anticoagulant proteins in liver cirrhosis
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | March 30, 2020 |
Est. primary completion date | September 1, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Patients diagnosed as liver cirrhosis confirmed clinical , biochemical and ultrasonography. - severity of cirrhosis was assessed according to Child-Pugh score and MELD score. Exclusion Criteria: - history of bleeding or thrombotic disorder, - history of renal disease, diabetes mellitus, - ongoing or recent pregnancy, - recent history of transfusion of blood products, - current anticoagulation therapy. - Hepatocellular carcinoma |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Assiut University |
Hessien M, Ayad M, Ibrahim WM, ulArab BI. Monitoring coagulation proteins during progression of liver disease. Indian J Clin Biochem. 2015 Apr;30(2):210-6. doi: 10.1007/s12291-014-0429-1. Epub 2014 Apr 19. — View Citation
Rai V, Dhameja N, Kumar S, Shukla J, Singh R, Dixit VK. Haemostatic Profile of Patients with Chronic Liver Disease- its Correlation with Severity and Outcome. J Clin Diagn Res. 2017 Aug;11(8):EC24-EC26. doi: 10.7860/JCDR/2017/24975.10451. Epub 2017 Aug 1. — View Citation
Tripodi A, Anstee QM, Sogaard KK, Primignani M, Valla DC. Hypercoagulability in cirrhosis: causes and consequences. J Thromb Haemost. 2011 Sep;9(9):1713-23. doi: 10.1111/j.1538-7836.2011.04429.x. Review. — View Citation
Wypasek E, Undas A. Protein C and protein S deficiency - practical diagnostic issues. Adv Clin Exp Med. 2013 Jul-Aug;22(4):459-67. — View Citation
Type | Measure | Description | Time frame | Safety issue |
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Primary | Assesment of haemostatic profile in different stages of liver cirrhosis | assessment of the level of protein C, S ,antithrombin in patients with liver cirrhosis, and correlate the level of these parameters with the degree of liver cirrhosis | baseline | |
Secondary | The value of anticoagulant use in patients with liver cirrhosis | Cirrhotic patients has bleeding disorders and also high possibility of developing thrmobosis , so secondary to this study which assess the cause of hypercoaguability state in liver cirrhosis, new studies can be based on this study to assess the value of use of anticoagulant therapy in cirrhotic patients who are at high risk of developing thrombosis | baseline |