Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT03580161 |
Other study ID # |
CCR 4767 |
Secondary ID |
|
Status |
Completed |
Phase |
|
First received |
|
Last updated |
|
Start date |
June 30, 2018 |
Est. completion date |
June 30, 2022 |
Study information
Verified date |
June 2023 |
Source |
Royal Marsden NHS Foundation Trust |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
This is a pilot study with the primary aim being to identify the minimum number of scans and
measurements necessary to determine accurately the absorbed radiation doses delivered from
internal sources of radiation administered for diagnostic nuclear medicine procedures.
Description:
A study to develop practical methods of accurate low radiation absorbed dose measurement in
patients referred for nuclear medicine scans.
There is currently very little information on and therefore understanding of the effects of
exposure to low levels of radiation on patients or radiation workers. Assumptions are largely
based on evidence from high radiation doses following nuclear incidents which may not be
applicable to medical procedures. Underestimation of the radiation effects incurs greater
risk to patients than is currently assumed, while overestimation can prevent more informative
scans that would be obtained from higher administered activities. This research study answers
an invitation from the Department of Health Policy research programme to improve our
understanding of those low radiation dose risks.
Over 600,000 patients have nuclear medicine scans in the UK each year, presenting an
opportunity to accurately measure low radiation doses and follow up the effects on a large
number of patients. This study will develop practical methods to measure accurately the
radiation doses delivered to patients referred for nuclear medicine positron emission
tomography (PET) and single photon emission computed tomography (SPECT) scans.
Five patients referred for each of 7 diagnostic nuclear medicine procedures will undergo up
to 7 quantitative PET/SPECT scans and up to 10 whole body radiation retention measurements
over the course of 1-2 days to enable the absorbed radiation doses to be calculated
accurately. Analysis of subsets of these measurements will be performed to identify the
timing and minimum number of measurements necessary for accurate dose estimates.
The longer term aim is that these methods and results will subsequently be used to inform a
national epidemiological (epidemiology is the study of factors affecting the health and
illness of populations) study on the effects of low doses of radiation.