Incretin Hormones in PCOS With Prediabetes Clinical Trial
Official title:
Reduced GLP-1 Response is Associated With Prediabetes in Women With Adverse Metabolic Phenotype of PCOS Independently of BMI
Women with PCOS are more prone to obesity which exacerbates insulin resistance, the abdominal
fat disposition and metabolic risk of these patients. With development of obesity these women
have high conversion rate from normal glucose tolerance to impaired glucose tolerance and in
turn to type 2 diabetes.
Glucagon-like peptide 1 (GLP-1) is involved in body weight maintenance. Beside energy balance
it is also involved in glucose homeostasis. Functional deficit in GLP-1 facilitates obesity.
We investigated the link between the concentration of incretin hormones and glucose
homeostasis, metabolic complications and the distribution of body composition in obese women
with PCOS.
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