Genotype, Metabotype and Dietary Habits Clinical Trial
Official title:
Association Between Genotype, Polyphenol Gut Microbiota Metabotypes, and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.
The objective of this study is to investigate the possible association between 60 SNPs related to obesity, metabolism and cardiovascular disease with BMI, intestinal microbiota and adherence to the Mediterranean diet in a cohort of children and adolescents from the southeast of Spain.
The objective of this study is to investigate the possible association between 60 single
nucleotide polymorphisms (SNPs) related to obesity, metabolism and cardiovascular disease
with the body mass index (BMI), intestinal microbiota related to the metabolism of
polyphehnos and adherence to the Mediterranean diet in a cohort of children and adolescents
from the southeast of Spain.
The volunteers (n=423) with ages ranging from 5 to 18 years consumed for three days a daily
serving of walnuts (30g) and provided a sample of urine (to determine mirobial-derived
metabolites from walnut polyphenols) as well as a swab specimen from the inner cheek to
provide DNA for further genotyping.
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