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Algorithm of Muscle Function Tests to Detect Residual Neuromuscular Blockade.

Postoperative Residual Curarization Clinical Trial

Official title:
Development of an Algorithm Using Clinical Tests to Avoid Post-operative Residual Neuromuscular Block

Clinical Trial Summary

Objective neuromuscular monitoring is the gold standard to detect postoperative residual curarization (PORC). Many anesthesiologist just use qualitative neuromuscular monitoring or unreliable, clinical tests. Goal of this study is to develop an algorithm of muscle function tests to identify PORC

Clinical Trial Description

Background: Quantitative neuromuscular monitoring is the gold standard to detect postoperative residual curarization (PORC). Many anesthesiologists, however, use insensitive, qualitative neuromuscular monitoring or unreliable, clinical tests. Goal of this multicentre, prospective, double-blinded, assessor controlled study is to develop an algorithm of muscle function tests to identify PORC.

Methods: After extubation a blinded anesthetist performs eight clinical tests in 165 patients. Test results are correlated to calibrated electromyography train-of-four (TOF) ratio and to a postoperatively applied uncalibrated acceleromyography. A classification and regression tree (CART) is calculated developing the algorithm to identify PORC. This is validated against uncalibrated acceleromyography and tactile judgement of TOF fading in separate 100 patients. ;

Study Design

Related Conditions & MeSH terms

  • Delayed Emergence from Anesthesia
  • Postoperative Residual Curarization
Clinical Trial Details
NCT number NCT03219138
Study type Interventional
Source University of Regensburg
Contact
Status Completed
Phase N/A
Start date January 8, 2008
Completion date July 25, 2009
View Details
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