Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Clinical Trial
Official title:
Phase 1, Open-label Dose-escalation and Dose-expansion Study to Evaluate the Safety, Expansion, Persistence and Clinical Activity of a Single Dose of UCART123 (Allogeneic Engineered T-cells Expressing Anti-CD123 Chimeric Antigen Receptor), Administered in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
A Phase 1 dose-finding study of Universal Chimeric Antigen Receptor T-cells targeting cluster of differentiation (CD) 123 (UCART123) administered intravenously to patients with relapsed or refractory Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN), followed by a dose expansion phase in relapsed or refractory BPDCN patients or newly diagnosed BPDCN patients.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT05645744 -
Long-term Follow-up Study in Patients Previously Treated With a Mustang Bio CAR-T Cell Investigational Product.
|
||
| Completed |
NCT02113982 -
SL-401 in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm or Acute Myeloid Leukemia
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04013685 -
Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
|
Phase 1 | |
| Active, not recruiting |
NCT03599960 -
Combination Chemotherapy in Patients With Newly Diagnosed BPDCN
|
Phase 2 | |
| Recruiting |
NCT05430971 -
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry
|
||
| Recruiting |
NCT04230265 -
Dose-escalating Trial With UniCAR02-T Cells and CD123 Target Module (TM123) in Patients With Hematologic and Lymphatic Malignancies
|
Phase 1 | |
| Terminated |
NCT04109482 -
Trial to Evaluate the Safety and Efficacy of MB-102 in Patients With BPDCN.
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06006403 -
Safety and Efficacy of CD123-targeted CAR-NK for Relapsed/Refractory Acute Myeloid Leukemia or Blastic Plasmacytoid Dendritic Cell Neoplasm
|
Phase 1/Phase 2 |