Recurrent Implantation Failure in Setting of Artifically Prepared Endometrium Clinical Trial
Official title:
A Randomized Study on the Value of an Endometrial Scratch Prior to a Frozen Embryo Transfer Cycle in the Treatment of Recurrent Implantation Failure
Patients with a history of recurrent implantation failure who are planning a frozen embryo transfer (FET) are enrolled into the program. Patients are randomized to an endometrial biopsy prior to starting estrogen to prepare for the transfer of warmed vitrified embryos or to routine care.
Patients who failed to achieve a clinical pregnancy after embryo transfer of at least three
high quality embryos in at least two IVF or FET cycles and for whom their last failed cycle
was a frozen embryo transfer are offered the opportunity to enroll in this study. All
patients will follow our routine FET protocol.
On a randomized basis, selected patients will undergo an endometrial biopsy using a Pipelle
disposable device in the week prior to starting estrogen to prepare her endometrium.
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