Liver Transplant Abscess Clinical Trial
Official title:
Risk Factors and Outcomes of Pyogenic Liver Abscess in Adult Liver Recipients: A Match Case Control Study
Objective: the aim of this study is to identify risk factors associated with the development
of pyogenic liver abscesses (PLA) in adult liver recipients (ALR) and to describe the
experience of the Hospital Italiano de Buenos Aires (HIBA) in the diagnosis and therapeutic
management of these patients.
Background: adult liver recipients differ from the general population with PLA as they
exhibit: reconstructed biliary anatomy, recurrent hospitalizations, regular performance
status and are subjected to immunosuppression. However, the scientific evidence regarding
PLA developed in transplanted organs is still scarce and the management of this disease
continues to be based on experience in non-transplanted patients.
Methods: between 1996 and 2016, 879 adult patients underwent liver transplantation (LT) at
our institution. Patients who developed PLA after LT (cases) and controls are matched
according to the time from transplant to abscess in a 1 to 5 relation. The investigators
performed a logistic regression model to establish PLA risk factors considering clusters for
matched cases and controls. Independent risk factors will be identified using multivariate
regression analysis.
Objective: the aim of this study is to identify risk factors associated with the development
of pyogenic liver abscesses (PLA) in adult liver recipients (ALR) and to describe the
experience of the Hospital Italiano de Buenos Aires (HIBA) in the diagnosis and therapeutic
management of these patients.
Background: adult liver recipients differ from the general population with PLA as they
exhibit: reconstructed biliary anatomy, recurrent hospitalizations, regular performance
status and are subjected to immunosuppression. However, the scientific evidence regarding
PLA developed in transplanted organs is still scarce and the management of this disease
continues to be based on experience in non-transplanted patients.
Methods: between 1996 and 2016, 879 adult patients underwent liver transplantation (LT) at
our institution. Patients who developed PLA after LT (cases) and controls are matched
according to the time from transplant to abscess in a 1 to 5 relation. The investigators
performed a logistic regression model to establish PLA risk factors considering clusters for
matched cases and controls. Independent risk factors will be identified using multivariate
regression analysis.
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