Aortic Bioprosthesis Structural Valve Dysfunction Clinical Trial
Official title:
Assessment of Osteoblastic Activity With 18F-Fluoride in Aortic Bioprosthesis Structural Valve Dysfunction (SVD)
Structural valve dysfunction (SVD) is the most common and life threatening complication in
patients treated by aortic valve replacement. A calcification process is frequently involved
in SVD but its pathophysiology remains unclear. In the hypothesis of an active metabolic
phenomenon of calcification, as previously shown in native aortic valve stenosis, rather than
a passive deposit of calcium in valve tissue, positon emission tomography (PET) imaging with
18F-Fluoride could emphasize increased osteoblastic activity in SVD tissue.
This study will include patients with echocardiography-confirmed SVD. Echocardiographic
parameters and other current parameters analyzed in SVD patients such as bioprosthesis
calcium scoring derived from CT will be compared to 18F-Fluoride activity.
n/a