Esthetic & Topographic Shifts From Facial Fillers Clinical Trial
Official title:
A Study of the Lifting Capacity of Fillers
Hyaluronic acid (HA) fillers are tested in-vitro to measure their lifting capacity,
viscosity, cohesivity, and rheologic properties, and their lifting capacity has been tested
in animal models. To date, there are no studies that measure the lifting capacity of fillers
in an in-vivo human model.
The intention is to study the lifting capacity of fillers in a group of patients by comparing
pre and post-procedure two and three-dimensional photographs using analytic software.
Specifically, the PI is interested in determining the amount of tissue elevation created by
injecting HAs Restylane-Lyft®, and Restylane-L® (Galderma Laboratories, L.P., Fort Worth, TX)
to the midface and to the lower face, both in the anterior-posterior direction and in the
vertical direction by using analytic software.
The research group has identified a reliable and reproducible quantitative assessment of
midfacial position called WIZDOM (Width of the InterZygomatic Distance Of the Midface) to
quantitatively evaluate the midface. It can be used as an objective tool to assess midfacial
rejuvenation, whether with fat, fillers, or midface or facelift surgery. The Distance from
WIZDOM to inner canthus, the WIZDOM -IC measurement increases with aging as the face deflates
and descends, and, in the practice, is also a means of assessing the midface in youth and in
aging. The PI's findings have been published in the Aesthetic Surgery Journal. The practice
will also attempt to utilize this metric as a measure of midface aesthetic lifting capacity.
The practice will also employ 3 D photography and analytic software to determine degree of
lift in mm in the y and z axis. (vertical and AP increase in dimension) pre and post-
injection. (Vectra, Canfield, Fairfield, NJ)
We will recruit patients from a population of subjects that generally would receive fillers
to improve changes associated with facial volume loss and divide them in to two groups based
on chronologic age.
All fillers will be injected in locations where the FDA has approved it for on-label
indications (the cheek, subcutaneously and supraperiosteally, the dermis and subdermis for
the correction of wrinkles and folds such as the nasolabial fold) and placed as usual and
customary using techniques as practiced by the authors and as are accepted widely.
Additional steps prior to injection for this study are temporary sterile magic marker
markings markers on the face and detailed photography, both 2D and 3D, that will be taken
before, during, and after injection, and the segmentation of injections such that the midface
will be injected prior to and separately from the lower face.
Three dimensional data will be analyzed using Vectra analytic software, and 2-D photographs
will be analyzed by measuring improvements in WIZDOM (width of the interzygomatic distance of
the midface) and its distance to the inner canthus.
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