The Minimum Effective Volume of Ropivacaine in Ultrasound-guided Supraclavicular Block

Supraclavicular Brachial Plexus Block Clinical Trial

Official title: The Minimum Effective Volume of Ropivacaine in Ultrasound-guided Supraclavicular Block

Status Completed

Clinical Trial Summary

The aim of this study is to determine the minimum effective volume of local anesthetic (ropivacaine 0.275% and 0.325%) required to produce an effective double-injection USG-SCB for surgical anesthesia in 90% of patients (MEV90) in young group (18-40 years) and in middle aged group (40-65 years) of patients scheduled for elective surgery of one upper limb distal to the shoulder.

Clinical Trial Description

The study is based on biased coin design, and the volume of LA for the next patient is determined by the result of the last one. In the case of block failure, the volume will be increased by 2ml. Conversely, block success will result in either a reduction in volume by 2ml (probability 11%) or no change in volume (probability 89%). A blinded assistant will assess sensory and motor blockade in each nerve territory ( the median, radial, ulnar and musculocutaneous nerves) at 10-min intervals up to 30 min after completion of the block. Finally, MEV90 is calculated by isotonic regression. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Supraclavicular Brachial Plexus Block

• NCT number: NCT02512471
• Study type: Interventional
• Source: Huazhong University of Science and Technology
• Status: Completed
• Phase: N/A
• Start date: May 2015
• Completion date: October 2015