Transposition of the Great Arteries Clinical Trial
Official title:
Cardiovascular Magnetic Resonance at Rest and Stress in Relation to Cardiopulmonary Exercise Capacity in Young Adults After Arterial Switch Operation (ASO) for Transposition of the Great Arteries (TGA)
Magnetic Resonance Imaging of the heart at rest and stress conditions relative to the cardiopulmonary exercise capacity in young adults after neonatal surgery for transposition of the great arteries.
After ASO obstruction of the transposed coronary arteries with resulting reduced perfusion
of the heart at stress or abnormities of the right ventricular blood flow resulting in
increasing heart rate as well as abnormities in pulmonary flow can appear. In this single
centre trial a large homogeneous group of young adults after surgery for transposition of
the great arteries (TGA), the so called artery switch operation (ASO), will undergo magnetic
resonance imaging (MRI) of the heart at rest and under drug- induced stress to receive data
of the functional status of the heart and its perfusion as well as data of the pulmonary
arterial perfusion.
Also obstruction of the pulmonary arteries will lead to reduced perfusion and
cardiopulmonary exercise capacity.
Therefore the MRI data will be compared to cardiopulmonary exercise capacity data determined
by cardio pulmonary stress test (CPX) concerning the feasibility of a correlation of the
data and possible generalisation of the results leading to long term assessment of coronary
perfusion and myocardial status after ASO for recommendations of physical activity of the
young adults.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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