Localized Aggressive Periodontitis Clinical Trial
Official title:
Efficacy of β-glucan in Treatment of Localized Aggressive Periodontitis: A Short Term Double-blinded, Placebo-controlled, Randomized Clinical Trial
combining the non-surgical therapy with a well-tolerated substance that can stimulate protective immune responses like B-glucan, might effectively mount resolution pathways contributing to resolving of the chronic lesion observed in aggressive forms of periodontal disease.
Aim: To investigate the efficacy of β-glucan supplementation to non-surgical periodontal
therapy in localized aggressive periodontitis (LAP) patients.
Method: 30 subjects were randomly and equally assigned to receive scaling and root planing;
either with placebo pills (Group I) or β-glucan (100 mg/once a day) (Group II), for 40 days.
Subjects were clinically monitored on day 0 and day 91. Gingival samples were harvested from
hopeless teeth sites to be investigated histologically and immunohistochemically using
matrix metalloproteinase (MMP)-1 and 9 antibodies form each patient; at the same time
intervals.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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