Diabetes Mellitus Type 1 Clinical Trial
Official title:
Influence of Occurrence of Remission and Its Duration on Development of Chronic Complications of Type 1 Diabetes and Patient Outcome
Natural course of diabetes mellitus involves gradual reduction of β cell mass within islets
of Langerhans in the pancreas. Symptoms of diabetes present when the mass of
insulin-producing cells reaches a point where insulin concentration does not suffice to
maintain proper glycaemia. In many patients β cells regenerate shortly after the diagnosis
of diabetes and initiation of insulin therapy. This phenomenon is called a remission.
The aim of this study is to asses the influence of occurrence and duration of remission on
development of chronic complications of diabetes and patients outcome.
Natural course of diabetes mellitus involves gradual reduction of β cell mass within islets
of Langerhans in the pancreas. Symptoms of diabetes present when the mass of
insulin-producing cells reaches a point where insulin concentration does not suffice to
maintain proper glycaemia. In many patients β cells regenerate shortly after the diagnosis
of diabetes and initiation of insulin therapy. This phenomenon is called a remission.
The aim of this study is to asses influence of occurrence and duration of remission on
development of chronic complications of diabetes and patients outcome.
Clinical remission was defined as time in which all of the following criteria were met:
HbA1c below 6.5 % , dose of exogenous insulin below 0.3 U / kg body weight and serum
C-peptide concentration above 0.5 ng / ml. Patients were divided into those who were in
remission at any time during follow-up (remitters) and non-remitters.
At follow-up occurrence of chronic microvascular complications of diabetes (retinopathy,
diabetic kidney disease and neuropathy) was evaluated.
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Observational Model: Case-Only, Time Perspective: Prospective
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