Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia

Patients With Febrile Neutropenia Clinical Trial

Official title: Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Following Administration by 4-hour Infusion and Bolus Injection.

Status Completed

Clinical Trial Summary

This is prospective and randomized study to compare the pharmacodynamics (t>MIC) of 0.5 g every 6 h of imipenem in twelve patients with febrile neutropenia following administration by a 4 h infusion or bolus injection.

Concentration of imipenem in plasma will be measured by HPLC method and simulated in Monte Carlo technique (Computer model) to get PK/PD index (40%T>MIC) and reported to %PTA (Probability Target Attainment) and %CFR (Cumulative Faction Response.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Febrile Neutropenia
• Fever
• Neutropenia
• Patients With Febrile Neutropenia

• NCT number: NCT02213783
• Study type: Interventional
• Source: Prince of Songkla University
• Status: Completed
• Phase: Phase 4
• Start date: February 2011
• Completion date: September 2013