Response of Viral Infection to Woodsmoke Clinical Trial
Official title:
Effects of Wood Smoke Particles on Influenza-induced Nasal Inflammation in Normal Volunteers
This study is focused on the pathophysiology underlying the association between exposure to
particulate pollutants and risk for/response to viral infection. The investigators
hypothesize that exposure to wood smoke particles (WSP) enhances influenza virus-induced
granulocyte and NK cell activation, via hyaluronic acid-mediated effects on IFNg production.
Oxidant stress and viral replication may also be affected. As an NIH funded ViCTER project,
the purpose of the study is also to test novel assays of granulocyte activation (Doershuk
lab) and lipid mediator activation (Albritton lab) which have not previously been used in
this type of research.
Healthy, nonsmoking adults age 18-40 years will be recruited. This is a randomized, placebo
controlled study comparing NLF granulocyte responses to LAIV administered after either WSP
or clean air, in normal healthy volunteers. Subjects receive either WSP or placebo (clean
air), followed by a standardized dose of LAIV and serial post-infection sampling of nasal
lavage fluids, nasal biopsy and blood
n/a
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)