Diabetes Mellitus Type 1 Clinical Trial
Official title:
The Role of ATGL and G0/G1 Switch Gene Complex in Lipopolysaccaride (LPS) Induced Ketosis - a Controlled, Randomised, Clinical Experimental Study
Hypothesis
1. To define whether stimulation of ATGL and suppression of G0/G1 switch gene occur in the
initial phases of diabetic ketoacidosis and thus can be identified as the primary
mechanisms behind this life threatening condition.
2. Make a human model for studying ketoacidosis.
The investigators plan to reduce in their regular insulin over night. In the morning we
administer endotoxin, which together with a relative lack of insulin will initiate
ketogenesis - a state of ketoacidosis. On another occasion strict glycemic control is
imposed by means of intravenous insulin. The testing is done two separate days with at least
3 weeks in between and patients are admitted to hospital the evening before the day of
testing. The investigators use isotopic tracers to determine metabolic fluxes and analyse
fat (ATGL, G0/G1 switch gene) and muscle biopsies.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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