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Pilot Study to Assess Lung Shunting of Yttrium-90 Microspheres Using PET/CT

Liver Metastases Clinical Trial

Official title:
PET/CT-Derived Hepatopulmonary Shunt Fraction Following Yttrium-90 Radioembolization

Clinical Trial Summary

This pilot clinical trial studies positron emission tomography (PET)/computed tomography (CT) in finding beads after Yttrium-90 bead therapy in patients with primary liver cancer or cancer that has spread to the liver (metastatic) that can not be removed by surgery. Imaging procedures, such as PET/CT after Yttrium-90 bead therapy, may help see if the beads are present in the lung and compare the results with the pre-therapy imaging.

Clinical Trial Description

PRIMARY OBJECTIVES: I. To estimate the absolute difference in post-therapy Yttrium-90 microsphere hepatopulmonary shunt fraction and the pre-therapy Technetium-99m macroaggregated albumin hepatopulmonary shunt fraction in patients with unresectable primary hepatic malignancy and hepatic metastatic disease. SECONDARY OBJECTIVES: I. To quantify and compare the pre-therapy Technetium-99m macroaggregated albumin particle sizes and post-therapy Yttrium-90 microsphere sizes. OUTLINE: Patients receive routine pre-therapy Technetium-99m macroaggregated albumin. Patients then undergo routine radioembolization with Yttrium-90 microspheres. Within 36 hours after radioembolization, patients undergo PET/CT imaging. Available imaging, clinical, interventional and surgical follow-up data for 2 years after completion of enrollment in the study will be obtained. ;

Study Design

Related Conditions & MeSH terms

  • Advanced Adult Primary Liver Cancer
  • Liver Metastases
  • Liver Neoplasms
  • Localized Unresectable Adult Primary Liver Cancer
  • Recurrent Adult Primary Liver Cancer
Clinical Trial Details
NCT number NCT02119065
Study type Observational
Source University of Cincinnati
Contact
Status Active, not recruiting
Phase
Start date January 30, 2014
Completion date December 31, 2024
View Details
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